A higher incidence of allergic reactions and injection-site reactions occurred in antibody positive patients [see Warnings and Precautions (5.1), Clinical Pharmacology (12.6)]
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Eating smaller, more frequent meals and staying hydrated can reduce early nausea
We have also added Figure 6, which summarizes all the GHSR dimers, the effects of these dimers as discussed in the paper, along with possible neuroanatomical locations important for these dimers
As a class, the GLPs are generally well tolerated
CNS GIPR and GLP-1R are essential for maximal weight loss To interrogate the importance of CNS GIPR for weight loss with mGIPR-Ab/GLP-1 treatment, HFD-fed Gipr fl/fl and Gipr Syn/ mice were treated IP with either vehicle or mGIPR-Ab/P1 every 6 days for 18 days